What is GVHD of the gut?

Chronic graft-versus-host disease (GVHD) of the gut happens when donated cells a patient receives during a blood or marrow transplant (BMT) begin attacking the gut, including the stomach and intestines.

GVHD of the gut can affect how food moves through the digestive system and how well nutrients are absorbed. Symptoms may range from mild to severe and can overlap with other conditions or side effects of treatment.

• Nausea or vomiting
• Loss of appetite or feeling full quickly
• Indigestion, gas or bloating
• Abdominal pain or cramping
• Diarrhea
• Unintentional weight loss

To learn more about how GVHD can affect different parts of your body, view our full list of GVHD symptoms.

You may be able to ease digestive symptoms and support nutrition through daily care, medicines and diet adjustments. Always talk with your care team before making changes.

• Keep a list of what you eat and how you feel after.
• Avoid foods that trigger symptoms, such as spicy, oily or fatty foods. Dairy can also cause problems for some people.
• Take anti-nausea medicines before meals if your doctor prescribes them.
• See a dietitian if you are losing weight. They can help you find foods that are easier to eat and keep you healthy.

• Avoid foods that seem to cause diarrhea, such as greasy foods, caffeine or milk products.
• Ask your doctor about anti-diarrhea medicines like Imodium or Lomotil.
• Drink plenty of fluids such as water, broths or electrolyte drinks to stay hydrated.

• Your stomach or intestines hurt.
• You notice changes in your appetite, stool or weight.
• You develop new or worsening nausea, diarrhea or vomiting.