How to prevent graft-versus-host disease (GVHD)

GVHD happens because of differences between your cells and the donated cells. It’s a common side effect of an allogeneic blood stem cell transplant.

Steps to lower risks of GVHD

Many people who had a transplant will have some GVHD, but there are some steps you can take to help lower your risk.

1. Take your medicines

Your doctor will give you medicine to help prevent GVHD. Keep taking that medicine as directed, even if you’re feeling healthy. Call your doctor right away if you are unable to take the medicine for any reason.

2. Watch for early warning signs

Tell your doctor if you notice early signs of GVHD. Early treatment of GVHD, infections and other side effects from treatment can make a big difference in your long-term recovery.

3. Protect yourself from the sun

Exposing yourself to the sun’s ultraviolet (UV) rays increases your risk of developing and worsening of GVHD. To limit your exposure to the sun:

Avoid the sun as much as possible.
Wear a hat, sunglasses, long sleeves and pants when you go out.
Apply SPF 50 or higher sunscreen on any skin that is not covered. You can also wear clothes with SPF for added protection. Don’t forget, even on a cool, overcast day the sun is just as harmful as on a hot, bright day.

The first step in preventing GVHD? A strong donor match

GVHD often starts with how well donor cells match your own. That’s why finding the most suitable HLA match is one of the most important steps in transplant success.

Learn how doctors choose the right donor and how our registry helps patients like you find their best match.

Learn how matching works Finding a donor

Learn more about GVHD and how it can affect your body

GVHD can look different for everyone. Where it shows up and how it feels depends on your body and your recovery. The more you know, the more prepared you’ll be to manage symptoms and protect your health. Explore these resources to learn more about how GVHD may affect specific areas: